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Zymogen. login jos889 In biochemistry, a zymogen ( / ˈzaɪmədʒən, - moʊ -/ [1] [2] ), also called a proenzyme ( / ˌproʊˈɛnzaɪm / [3] [4] ), is an inactive precursor of an enzyme A zymogen requires a biochemical change (such as a hydrolysis reaction revealing the active site, or changing the configuration to reveal the active site) for it to