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Initial dose: 12. cravit levofloxacin 500 mg obat apa 5 mg orally once or twice a day Titration and Maintenance dose: May increase total daily dose in increments of 25 mg to 50 mg per day to a target dose of 300 mg to 450 mg per day (administered in divided doses) by the end of week 2. sodium bicarbonate 500 mg obat apa Subsequent dose increases can be in increments of up to 100 mg once or twice weekly

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